From the preview:
During the summer of 1565, the Ottoman Empire laid siege to the island of Malta in the Mediterranean. Vastly outnumbered, the Knights Hospitaller and local Maltese defenders withstood the siege for nearly four months until a relief force arrived in early September. The victory became one of the defining moments of sixteenth-century European, celebrated across the continent.
Soon after, Jean Parisot de Valette, the Grand Master of the Knights, commissioned the construction of a fortified city on the island to discourage future attacks.
In Valletta, you contribute to this city’s construction, competing to score the most points by gathering resources and constructing buildings. Players have a variety of tools at their disposal to achieve victory. As the game progresses, construction projects earn players new cards with a variety of powers that they may add to their decks as they compete to be the most successful builder.