From the website:
MacGuffin (n) - the object in a story that everyone wants, but which might have little or no explanation as to what it actually is.
Get the MacGuffin is a quick game where players must make clever use of a limited hand of cards ranging from ridiculously powerful to just ridiculous. A calculated risk might gain you the coveted MacGuffin, but can you hold onto it until the last card is played? Is the MacGuffin even out there at all?
To start, deal the cards out equally (maximum five cards). Set the remaining few cards aside. On your turn, either play a card, discard an Object, or use the power of an Object. There are several powerful cards that may become yours during the course of gameplay. The player with the MacGuffin will frequently win the game, but holding onto that card can prove quite difficult! When you're out of cards, you're out of luck!