One of the classic card games that people tend to play when getting together is Rummy. There's dozens of varieties to choose from out there, so you never have to worry about the game getting stale. If you've got a favorite, but want to try something new, you should check out Log Cabin Rummy, they're up on Kickstarter now.
Log Cabin Rummy adds in Goal Cards and removes the Point Tally phase. The goal cards dictate what sort of sets and runs you are to create. When you finish the Goal card dealt to you, you get a new one. When the round is over (after someone has emptied their hand), the player who has completed the most Goal cards is the winner.
The campaign focuses primarily on getting the Goal Card deck created. The campaign is set to run for another 24 days.