Gamers can be resistant to change. They know one gaming system, and they may not want to have to learn the rules for a new one. That can be tough if you don't want to keep playing in the same setting all the time. Thankfully, there's those out there that are changing up the locations of games but still using the rules you know. Take Genefunk 2090. It's a biopunk/cyberpunk setting using the OGL rules system. It's also up on Kickstarter now.
From the campaign:
GeneFunk 2090 is a biopunk/cyberpunk RPG and setting made using the D&D 5E Open Gaming License. Players take on the role of elite mercenaries that specialize in investigation and violence. No magic or fantasy, but tons of cybernetics, genetic enhancements, nanobots, drones, hacking, androids, high tech guns and armor, and other amazing tech!
Cadre of Professionals. You and your allies are a cadre, a lean start-up corporation that specializes in investigation, intelligence, protection, and violence. To keep their hands clean, the syndicates often outsource this kind of work to smaller outfits, like yours. Your cadre's skillset is in high demand in this intrigue filled world, being sought after by megacorporations, nation-states, organized crime, or wealthy individuals. As an autonomous entity, your cadre of elite agents takes contracts as you see fit, navigating the shadows of corporate espionage and savagery with competence and panache. Discreet. Elite. Disposable.
The campaign's about 3/4 of the way to its goal with 29 days to go.