The Genesys system was designed to be setting-agnostic. It was made to be able to plug into every setting possible. With the upcoming Expanded Player's Guide, Fantasy Flight is giving you several more settings that you can add it to. Want to see what's coming? Check out this new preview.
From the post:
In Genesys, the only limitation is your imagination. The settings are limitless, and the adventures infinite. While the system offers complete freedom to make whatever world you envision, it also gives you the tools you need to begin your journey, including plenty of sample settings to base your world on.
Join us today as we preview the new settings found in the Expanded Player’s Guide for Genesys Roleplaying!
These settings draw inspiration from a diverse range of media—from the epic legends and myths of past civilizations, to the classic horror literature and films of the late nineteenth and early twentieth centuries, to the desperate stories of societal collapse that captivate our imaginations today.
Each of these settings includes new character creation options, equipment and weapons, and adversaries to challenge your characters. These settings provide a broad overview and starting point for building your own games in these universes, including tips on how to strike the appropriate tone and tell compelling stories.