Fantasy Flight Games caused a lot of conversation with their KeyForge game, where each and every single deck would be 100% unique from every other one. But that was a "simple" card game. Discover: Lands Unknown is a 100% unique board game. Each box will have different components, from different meeples, to monsters, to mats. No two games will be entirely alike.
From the website:
Discover: Lands Unknown is a new adventure for Fantasy Flight Games, joining KeyForge as one of our first Unique Games. What is a Unique Game? In a nutshell, it's an entirely new type of game! Unique Games can take many different forms, but they share one thing in common—every copy of the game is unique. The copy that you pick up off the shelf will have different components than the copy your friend gets at their store.
While mechanics and some common components like meeples will be the same in every copy of the game, the vast majority of the cards, tiles, and tokens in your box will be randomized, selected from a vast pool of possible components. When you open your copy of Discover: Lands Unknown, you can never be sure what you'll find inside, and the combination will be different from every other copy in the world. In other words, Unique Games aren't like Legacy Games, which start with identical components, but become unique through gameplay. Unique Games have their own distinct mix of components in every box!